Reference of 52273-77-5 , The common heterocyclic compound, 52273-77-5, name is 2-(3-Aminophenyl)ethanol, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 4 A mixture of 9-chloro-3-methoxyacridine, (975 mg, 4 mmol), 3-aminophenethyl alcohol (549 mg, 4 ml) and methanesulfonic acid (0.32 ml, 5 mmol) in methanol (30 ml) is stirred under reflux for 2 hours. The mixture is concentrated in vacuo, and the residue is dissolved in methanol (10 ml). The solution is diluted with ether (150 ml). The precipitates are collected by filtration, washed with ether to give 9-[3′-(beta-hydroxyethyl)anilino]-3-methoxyacridine, as the methanesulfonate (1.15 g, 65%), mp 186-188 C. Microanalyses Calculated for C22 H20 N2 O2 –CH3 SO3 H: C, 2.71; H, 5.49; N, 6.36; S, 7.28%. Found: C, 62.79; H, 5.51; N, 6.14; S. 7.17%.
The synthetic route of 52273-77-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sloan-Kettering Institute For Cancer Research; US5229395; (1993); A;,
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