As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 23377-40-4
S13: A suspension of 3-hexadecyloxypropan-l-ol (1.58 g, 5.26 mmol) and DIPEA (0.92 mL, 5.26 mmol) in anhydrous acetonitrile (25 mL) was treated dropwise over a 10 min period with 3-((chloro(diisopropylamino)phosphino)oxy)-propanenitrile (1.2 mL, 5.26 mmol). After 18 h at rt, the mixture was quenched with sat. aq. NaHC03 (15 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic phases were concentrated by rotary evaporation, and flash chromatography (column volume 25 mm x 140 mm, 10 to 20% gradient of EtOAc in hexanes) provided S13 (1.40 g, 53%) as a white solid: 1H NMR (400 MHz, CDC13) delta 3.89 – 3.54 (m, 6H), 3.49 (t, 7= 6.3 Hz, 2H), 3.39 (t, 7= 6.7 Hz, 2H), 2.64 (t, J = 6.6 Hz, 2H), 1.87 (p, J = 6.3 Hz, 2H), 1.57 (p, J = 6.3 Hz, 2H), 1.25 (s, 26H), 1.18 (dd, J = 6.8, 3.5 Hz, 12H), 0.87 (t, J= 6.6 Hz, 3H); 31P NMR (162 MHz, CDC13) delta 147.40.
With the rapid development of chemical substances, we look forward to future research findings about 23377-40-4.
Reference:
Patent; EMORY UNIVERSITY; PAINTER, George, R.; GUTHRIE, David, B.; BLUEMLING, Gregory, R.; NATCHUS, Michael, R.; (179 pag.)WO2017/156380; (2017); A1;,
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