Reference of 16545-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16545-68-9, name is Cyclopropanol, molecular formula is C3H6O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,6-dichloro-9-cyclopropylpurine2,6-Dichloropurine (1 mmol), triphenylphosphine (1.3 mmol), tetrahydrofurane (5 ml) and cyclopropanol (5 mmol) were stirred at it under nitrogen to give clear yellowish solution, which was then cooled to 0 C and diisopropyldiazadicarboxylate (DIAD; 1.3 mmol) was added via syringe. The reaction mixture was then stirred at rt for 12 h. After evaporation of the solvents the product was extracted with diethylether and purified by column chromatography (silicagel, 1% MeOH in CHCl3). Crystallization from methanol gave the product in yield 35 %, mp 121-124 C.
According to the analysis of related databases, 16545-68-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERZITA PALACKEHO V OLOMOUCI; BIOPATTERNS s.r.o.; ZATLOUKAL, Marek; KRYSTOF, Vladimir; HAVLICEK, Libor; POPA, Igor; DOLEZAL, Karel; STRNAD, Miroslav; WO2010/139289; (2010); A1;,
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