Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H11ClO3, blongs to alcohols-buliding-blocks compound. COA of Formula: C6H11ClO3
EXAMPLE 1 Preparation of (S)-3-Hydroxy-gamma-butyrolactone To 500 g (3 mol) of ethyl (S)-4-chloro-3-hydroxybutyrate (produced by Takasago International Corporation; purity: 98percent; optical purity: 93percent ee) was added 1 l of 0.5N hydrochloric acid, and the solution was heated under reflux for 2 hours. After cooling, the reaction solution was neutralized with a 50percent aqueous solution of sodium hydroxide, and water was evaporated under reduced pressure. To the residual mixture of crystals and an oily substance was added 500 ml of ethyl acetate, followed by stirring. The crystals were removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was distilled under reduced pressure to give 232 g of the title compound as a colorless substance (purity: 99percent; yield: 75percent). Boiling point: 140¡ã C./1 mmHg Optical rotation: [alpha]D24 =-79.53¡ã (c=2.07, ethanol) 1 H-NMR (CDCl3) delta ppm: 2.51 (1H, d, J=18 Hz), 2.76 (1H, dd, J=6, 18 Hz), 3.71 (1H, brs, OH), 4.31 (1H, d, J=10.3 Hz), 4.42 (1H, dd, J=4.4, 14.7 Hz), 4.65-4.69 (1H, m, CH–OH)
The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takasago International Corporation; US5780649; (1998); A;,
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