Adding a certain compound to certain chemical reactions, such as: 534-03-2, 2-Aminopropane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
The preparation of (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodo-phenyl)amino)-1-oxopropan-2-yl acetate was carried taking as reference the procedures described in the literature. 20 g (28.2 mmol) of (S)-1-((3,5-bis(chlorocarbonyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate from example 3 was reacted with 2-amino-1,3-propanediol (6.4 g, 70.5 mmol) in DMA (100 ml) in the presence of triethylamine (10.0 ml, 71.4 mmol) at 50 C. for 6 hours. After complete reaction and removal of the salts by filtration, the solvent was distilled under vacuum at below 70 C. until a viscous oil was obtained. While the residue was still hot, alcohol was added (20 ml) to fluidize, followed by the addition of acetone (120 ml) in portions for about 1 hour and reflux for another hour. The resulting suspension was filtered and the product was dried under vacuum at 50 C. for 16 hours to give (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate as a white solid (19.0 g, 23.1 mmol). [0026] Yield: 82.0% [0027] HPLC purity: 98% (including 2% lopamidol)
The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HOVIONE INTER LIMITED; Galindro, Jose Manuel; Cruz, Ana Cristina; Bandarra, Joao Jose; Heggie, William; US2014/155648; (2014); A1;,
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