Adding a certain compound to certain chemical reactions, such as: 456-47-3, 3-Fluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H7FO, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H7FO
Aniline (46.5 mg, 0.5 mmol),Cat.[Ir] (5.4 mg, 0.005 mmol, 1 mol%), cesium carbonate (49 mg, 0.15 mmol, 0.3 equiv.),3-Fluorobenzyl alcohol (75.6 mg, 0.6 mmol) and t-amyl alcohol (1 ml) were sequentially added to a 5 mL round-bottomed flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.The solvent is removed by rotary evaporation and then passed through column chromatography (developer:Petroleum ether/ethyl acetate gives the pure target compound, yield: 95%.
The synthetic route of 456-47-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing University of Science and Technology; Fan Hongjun; Li Shun; Liu Pengcheng; Li Feng; (9 pag.)CN107778182; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts