Reference of 5020-41-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.1904, as common compound, the synthetic route is as follows.
28.90 g (0.217 mol) of aluminum chloride was slurried in 400 mL of methylene chloride under a N2 atmosphere and cooled to 0 C. 15.0 g (0.0985 mol) of 2-(3-Methoxy-phenyl)-ethanol and 17.02 g (0.217 mol) of acetyl chloride were combined in methylene chloride and following the exotherm, this solution was added dropwise to the aluminum chloride slurry at 0 C. The reaction mixture was allowed to stir at 0 C. for 1 h and at ambient temperature for 45 min. The reaction was carefully poured into 1M HCl (300 ml) and the aqueous layer was extracted with dichloromethane (3×100 ml) and the combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford crude product which was loaded onto a silica gel column. Using 20% ethyl acetate in hexane yielded 17.94 g (77%) of Acetic acid 2-(2-acetyl-5-methoxy-phenyl)-ethyl ester 38. 1H NMR (CDCl3): 2.00 (s-3H), 2.54 (s-3H), 3.24 (t-2H), 3.84 (s-3H), 4.28 (t-2H), 6.75-6.81 (m-2H), 7.77 (d-1H; J=8.52 Hz).
Statistics shows that 5020-41-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Methoxyphenyl)ethanol.
Reference:
Patent; Pfizer Inc., Pfizer Inc.; US2004/77853; (2004); A1;,
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