Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Cyclopropanol, blongs to alcohols-buliding-blocks compound. name: Cyclopropanol
Diisopropylethylamine (0.142 mL, 0.811 mmol), HBTU (0.184 g, 0.486 mmol), and crude cyclopropanol (0.0470 g, 0.811 mmol) were added to a solution of 2-(2-(3-(4-(dimethylamino)piperidin-1-yl)-3-oxopropyl)-1H-imidazol-1-yl)acetic acid (0.100 g, 0.324 mmol) in chloroform (6.0 mL) at room temperature, and the reaction liquid was stirred at the same temperature for 16 hours. Hydrochloric acid (1.0 N) was added to the reaction liquid, and then the reaction liquid was back-extracted. A saturated aqueous solution of sodium hydrogencarbonate was added to the obtained aqueous layer for neutralization, and then the resulting mixture was extracted with chloroform. The organic layer was washed with a 10% aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to obtain cyclopropyl 2-(2-(3-(4-(dimethylamino)piperidin-1-yl)-3-oxopropyl)-1H-imidazol-1-yl)acetate (0.0610 g, 0.175 mmol, 54%) (hereinafter referred to as a ?compound of Example 44?) as a colorless oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16545-68-9, Cyclopropanol, and friends who are interested can also refer to it.
Reference:
Patent; TORAY INDUSTRIES, INC.; MORITA, YASUHI; IZUMIMOTO, NAOKI; ISEKI, KATSUHIKO; IWANO, SHUNSUKE; UDAGAWA, SHUJI; MIYOSHI, TOMOYA; OSADA, YUJI; KOREEDA, TETSURO; MURAKAMI, MASANORI; SHIRAKI, MOTOHIRO; TAKAHASHI, KEI; OSHIDA, KEIYU; (177 pag.)TW2016/2093; (2016); A;,
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