Electric Literature of 75853-18-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75853-18-8, name is 2,3-Difluorobenzyl alcohol. A new synthetic method of this compound is introduced below.
Example 218: 4-[2-(2,3-Difluorobenzyloxy)ethyl]piperidine-l-carboxylic acid tert-butyl esterA stirred solution of (2,3-difluorophenyl)methanol (50 mg, 350 mumol) in anhydrous THF (2 mL) was treated with tBuOK (47 mg, 42 mumol) and then 4-(2-methanesulfonyloxy- ethyl)piperidine-l-carboxylic acid tert-butyl ester (Preparation 10) was added. The resulting mixture was heated under reflux for 12 h, cooled and poured into saturated aqueous NH4Cl, and extracted with EtOAc (20 mL). The organic phase was washed with brine (5 mL), dried (MgSO4) and evaporated. The residue was purified by column chromatography (IH-EtOAc, 4: 1) to afford the title compound: RT = 4.39 min; m/z (ES+) = 356.1 [M+ H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,75853-18-8, 2,3-Difluorobenzyl alcohol, and friends who are interested can also refer to it.
Reference:
Patent; PROSIDION LIMITED; WO2007/3962; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts