As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C7H5BrF2O
A mixture of 48% HBr (130 mL, 1149 mmol) and (4-bromo-2,6- difluorophenyl)methanol (40 g, 179 mmol) was heated to reflux overnight. After cooling to room temperature, the reaction mixture was poured into 80 mL of water and was extracted with hexanes (2 x 300 mL). The combined organic layers were washed with sodium bicarbonate solution, dried over MgSO4, filtered, and concentrated to afford 5 -bromo-2-(bromomethyl)- 1,3 -difluorobenzene. ?H NMR (CDC13, 300 MHz) (ppm): 6.94-7.22 (m, 2H), 4.46 (s, 2H).
With the rapid development of chemical substances, we look forward to future research findings about 162744-59-4.
Reference:
Patent; FORMA THERAPEUTICS, INC.; ZABLOCKI, Mary-Margaret; GUERIN, David J.; NG, Pui Yee; WANG, Zhongguo; SHELEKHIN, Tatiana; CARAVELLA, Justin; LI, Hongbin; IOANNIDIS, Stephanos; (518 pag.)WO2019/32863; (2019); A1;,
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