The origin of a common compound about 575-03-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

Similarly, the reaction of 4-nitrophthalonitrile (1.00 g, 5.78 mM) with 7-hydroxy-4-trifluoromethylcoumarin(1.33 g, 5.78 mM) was initiated in 30 mL of DMF in the presence of K2CO3 (2.30 g, 16.6 mM). The reaction mixture was heated with stirring at 90 ¡ãC under an inert nitrogen atmosphere for 24 h. Thereafter, the reaction mixture was cooled to room temperature, poured into 60 mL water, and extracted with CH3CN. The combined organic extracts were dried over sodium sulfate and filtered. The solvent was evaporated under reduced pressure and the remaining residue was added to 30percent HCl to induce precipitation. The precipitate was then repeatedly washed with water and added to hot methanol (MeOH), filtered, and dried under P2O5. Yield: 41percent; m.p. (¡ãC): 180.0?181.8; FT-IR (numax/cm?1): nu(C=O) 1729, nu(C?N) 2235, nu(C?O?C) 990, 1129; 1H NMR (ppm): 7.06 (s, 1H, H1), 7.99 (s, 1H, H2), 7.64 (d, 1H, J = 8.73 Hz, H3), 8.19 (d, 1H, J = 8.74 Hz, H4), 7.43 (s, 1H,H5), 7.28 (d, 1H, J = 8.80 Hz, H6), 7.80 (d, 1H, J = 9.01 Hz, H7); 13C NMR (ppm): 159.78, 158.74, 158.42, 156.01, 146.85, 137.01, 127.37, 124.64, 124.38, 123.44, 117.57, 117.21, 116.26, 116.11, 115.69, 110.82, 110.40, 109.04; UV?Vis [DMF, lambdamax (epsilon, M?1 cm?1)]: 443 nm (90), 318 nm (29875), 307 nm (33370). Molecular mass (m/z): Calcd: 356.25. Found: 379.03 [M + Na]+. Anal. Calcd for C18H7F3N2O3 (percent): C, 60.68; H, 1.98;N, 7.86. Found: C, 60.48; H, 2.30; N, 7.86.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chohan, Sumayya; Booysen, Irvin Noel; Mambanda, Allen; Akerman, Matthew Piers; Journal of Coordination Chemistry; vol. 68; 10; (2015); p. 1829 – 1846;,
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