Application of 2566-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Iodine (3.05 g, 24.0 mmol) and imidazole(1.63 g, 24.0 mmol) were added to a solution of triphenylphosphine(6.29 g, 24.0 mmol) in chloroform (50 mL) at 0C under anitrogen atmosphere, and the mixture was stirred at the sametemperature for 15 min. A solution of 2-cyclopropylethanol(1.72 g, 20.0 mmol) in chloroform (50 mL) was added dropwiseto the reaction mixture, and the mixture was stirred at roomtemperature for 3 h. To the reaction mixture were added saturatedaqueous sodium thiosulfate solution (60 mL) and water (60 mL), and the mixture was extracted with chloroform. Theorganic layer was concentrated under reduced pressure, andthe resulting residue was purified using a silica gel columneluted with 100% n-hexane to afford the desired product(2.14 g, 55%) as a pale yellow oil.Triphenylphosphine (2.86 g, 10.9 mmol) was added to a solutionof the above product (2.14 g, 10.9 mmol) in acetonitrile(5 mL), and the mixture was heated at reflux temperature for15 h. After cooling to room temperature, diethyl ether wasadded to the mixture, and the resulting precipitates were collectedby filtration to afford the target intermediate (3.87 g,77%) as a colorless powder. To a suspension of the above intermediate (3.83 g,8.36 mmol) in THF (60 mL) was added dropwise potassiumhexamethyldisilazane (toluene solution, 0.5 mol/L) (16.7 mL,8.36 mmol) at 0C under a nitrogen atmosphere, and the mixturewas stirred at room temperature for 1 h. After coolingto 0C, a solution of 3-fluoro-4-nitrobenzaldehyde (1.23 g,7.27 mmol) in THF (10 mL) was added dropwise to the reactionmixture, and the mixture was stirred at room temperaturefor 1 h. Saturated aqueous ammonium chloride solution wasadded to the reaction mixture, and the mixture was extractedtwice with ethyl acetate. The organic layer was washed withbrine, dried over anhydrous MgSO4, filtered, and concentratedunder reduced pressure. The resulting residue was purifiedusing a silica gel column eluted with 25% ethyl acetate-nhexaneto afford 24 (1.42 g, 88%) as a brown oil: 1H-NMR(300 MHz, CDCl3) delta: 0.07-0.21 (2H, m), 0.45-0.60 (2H, m),0.74-0.92 (1H, m), 2.14-2.30 (2H, m), 5.96-6.11 (1H, m),6.36-6.45 (1H, m), 7.12-7.31 (2H, m), 7.98-8.08 (1H, m).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2566-44-1, 2-Cyclopropylethanol.
Reference:
Article; Busujima, Tsuyoshi; Tanaka, Hiroaki; Iwakiri, A. Kanako; Shirasaki, Yoshihisa; Munetomo, Eiji; Saito, Masako; Masuko, Aiko; Kitano, Kiyokazu; Io, Fusayo; Kato, B Koji; Kamigaso, Shunsuke; Nozoe, Akiko; Sato, Nagaaki; Chemical and Pharmaceutical Bulletin; vol. 64; 3; (2016); p. 228 – 238;,
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