Reference of 3068-00-6 ,Some common heterocyclic compound, 3068-00-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of 2,2-Dilinoleyl-4-(2-hydroxyethylH1 ,31-dioxolane (II)A mixture of dilinoleyl ketone (I, previously prepared as described in Example 1 , 527 mg, 1.0 mmol), 1 ,3,4-butanetriol (technical grade, ca. 90%, 236 mg, 2 mmol) and pyridinium p-toluenesulfonate (50 mg, 0.2 mmol) in 50 mL of toluene was refluxed under nitrogen overnight with a Dean-Stark tube to remove water. The resulting mixture was cooled to room temperature. The organic phase was washed with water (2 x 30 mL), brine (50 ml_), and dried over anhydrous Na2SO4. Evaporation of the solvent resulted in a yellowish oily residual (0.6 g). The crude product was purified by column chromatography on silica gel (230-400 mesh, 100 mL) with dichloromethane as eluent. This afforded 0.5 g of pure H as colourless o. 1H NMR (400 MHz, CDCI3) delta: 5.25- 5.48 (8H, m, 4 x CH=CH), 4.18-4.22 (1 H, m, OCH), 4.08 (1 H, dd, OCH), 3.82 (2H, t, OCH2), 3.53 (1 H, t, OCH), 2.78 (4H, t, 2 x C=C-CH2-C=C), 2.06 (8H, q, 4 x allylic CH2), 1.77-1.93 (2H, m, CH2), 1.52-1.68 (4H, m, 2 x CH2), 1.22-1.45 (32H, m), 0.86-0.94 (6H, t, 2 x CH3) ppm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3068-00-6, 1,2,4-Butanetriol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TEKMIRA PHARMACEUTICALS CORPORATION; THE UNIVERSITY OF BRITISH COLUMBIA; HOPE, Michael, J.; SEMPLE, Sean, C.; CHEN, Jianxin; MADDEN, Thomas, D.; CULLIS, Pieter, R.; CIUFOLINI, Marco, A.; LAHERTY, Carol, D.; MUI, Barbara; WO2010/42877; (2010); A1;,
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