With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, molecular weight is 231.04, as common compound, the synthetic route is as follows.Application In Synthesis of (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol
General procedure: To the solution of alcohol 4b (0.50 g, 2.67 mmol) and DMSO (0.41 g, 5.34 mmol) in ethyl acetate (5 ml) was added T3P (1.84 g, 6.68 mmol, 2.5 equiv, 50% solution in ethyl acetate) at 0 C. The resulting mixture was allowed to warm to RT and stirred for 1 h. Pyrazine-2-amine 3a (0.254 g, 2.67 mmol) was added to the above mixture and stirred for 15 min, which was followed by the addition of isocyanide 1c (0.33 g, 4.01 mmol) at room temperature and stirring for 4 h. Progress of the reaction was monitored by TLC. After the reaction was complete, the reaction mixture was diluted with ethyl acetate and neutralized with aqueous sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (25 mL ¡Á 2), the combined organic phases were washed with water, brine solution, dried over anhydrous sodium sulfate, and concentrated under vacuum to afford a crude product, which was purified on silica gel using ethyl acetate and petroleum ether.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6642-34-8, (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Ramesha, Ajjahalli B.; Raghavendra, Goravanahalli M.; Nandeesh, Kebbahalli N.; Rangappa, Kanchugarakoppal S.; Mantelingu, Kempegowda; Tetrahedron Letters; vol. 54; 1; (2013); p. 95 – 100;,
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