Electric Literature of 22436-06-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol. A new synthetic method of this compound is introduced below.
Example 115.1 g (100 mmol) of 2-methyl-3-phenylpropanol were introduced as initial charge in 87 g of dichloromethane. Over the course of 4 hours, 13.4 g (100 mmol) of AlCl3 and 9.3 g (100 mmol) of tert-butyl chloride were added at a temperature of 1-10 C. The mixture was heated to room temperature and worked-up with water and sodium hydroxide solution and the solvent was removed. This gave a mixture with the following composition: 2-methyl-3-(3-tert-butylphenyl)propanol (41%); 2-methyl-3-(4-tert-butylphenyl)propanol (24%); 3-(3,5-di-tert-butylphenyl)-2-methylpropanol (19%); 2-methyl-3-phenylpropanol (15%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,22436-06-2, (S)-2-Methyl-3-phenylpropan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; BASF SE; US2012/209030; (2012); A1;,
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Alcohols – Chemistry LibreTexts