Adding a certain compound to certain chemical reactions, such as: 7589-27-7, 2-(4-Fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(4-Fluorophenyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-(4-Fluorophenyl)ethanol
NaH 60percent suspension in mineral oil (2.400 g, equivalent to 1 .440 g of NaH, 60 mmol, 2 eq) was weighed into a flame-dried flask and suspended in dry D F (60 mL) with stirring, under a nitrogen atmosphere. To this was added 4 (4.205 g, 3.751 mL, 30 mL) and the temperature raised to 60 ¡ãC with stirring for 15 minutes. Chloroacetic acid (2.835 g, 30 mmol, 1 eq) was added to the flask and the mixture allowed to stir at 60 ¡ãC for a further 2.5 h. After cooling and removal of solvent, the residue was suspended in Et20 (30 mL) and extracted with water (2 x 30 mL). The combined aqueous layers were acidified with aqueous 2 HCI (to around pH 3) before extraction with EtOAc (3 x 30 mL). After removal of solvent, the crude solid was recrystallised from cyclohexane to yield 3.000g of pink crystals.
The synthetic route of 7589-27-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda; WO2012/4549; (2012); A1;,
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