Application of 99725-13-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99725-13-0, name is (5-Bromo-2-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
B. 5-Bromo-2-fluoro-benzyl bromide. To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10 C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 minutes at room temperature. The crude product is purified by column chromatography eluding with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol). 1 H NMR (CDCl3, 300 MHz) delta7.50 (dd, 1H), 7.37 (m, 1H), 6.92 (t, 1H), 4.42 (s, 2H). EI MS, [M]+ =266, 268, 270; 2 Br pattern.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 99725-13-0, (5-Bromo-2-fluorophenyl)methanol.
Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US6034093; (2000); A;,
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