New downstream synthetic route of Methyl 2-hydroxy-3-phenylpropanoate

The synthetic route of 13674-16-3 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate, the common compound, a new synthetic route is introduced below. HPLC of Formula: C10H12O3

Methyl 2-Methanesulfonyloxy-3-phenylpropionate (34) A dichloromethane solution of methyl 2-hydroxy-3-phenylpropionate (33) is treated with triethylamine (1.1 equiv) and methanesulfonyl chloride (1.1 equiv) at 0 C. Upon completion of reaction, the mixture is dissolved in dichloromethane/ether and washed with saturated aqueous solution of sodium chloride, dried and concentrated. Purification of crude material by flash column chromatography (40% ethyl acetate in hexane) gives methyl 2-methanesulfonyloxy-3-phenylpropionate (1.6 g, 93%). 1 H NMR (300 MHz CDCl3): delta 7.358-7.233 (m, 5H), 5.173 (dd, 4.26 Hz, 8.8 Hz, 1H), 3.793 (s, 3H), 3.301 (dd, 4.23 Hz, 14.38 Hz, 1H), 3.1295 (dd, 8.8 Hz, 14.3 Hz, 1H), 2.766 (s, 3H).

The synthetic route of 13674-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck & Co., Inc.; US5194605; (1993); A;,
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New learning discoveries about 1-(2,6-Dichloro-3-fluorophenyl)ethanol

With the rapid development of chemical substances, we look forward to future research findings about 756520-66-8.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 756520-66-8

Compound 1 – (2, 6 – dichloro -3 – fluoro phenyl) ethanol (4.6 g, 22 mmol), P2 O5 (17.5 G, 0 . 12 muM, 5.6 eq.) and DCM (200 ml) of the reaction suspension at room temperature 16 hours, filtering, filtering solid, solid for DCM (200 ml) washing, Na filtrate saturation2 CO3 Aqueous solution (100 ml x 2) washing, separating, the obtained organic phase with anhydrous Na2 SO4Drying, concentrated under reduced pressure, the concentrate produced in the process of filtering the white solid, the obtained oily material vacuum drying to obtain the crude product of the title compound (3.5 g, 83%), without further purification, is directly used for the next step reaction

With the rapid development of chemical substances, we look forward to future research findings about 756520-66-8.

Reference:
Patent; (88 pag.)CN104119331; (2018); B;,
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Sources of common compounds: 2,2′-Oxybis(ethan-1-ol)

According to the analysis of related databases, 111-46-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 111-46-6, Adding some certain compound to certain chemical reactions, such as: 111-46-6, name is 2,2′-Oxybis(ethan-1-ol),molecular formula is C4H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111-46-6.

2-(2-(Prop-2-ynyloxy)ethoxy)ethanol (10) To a stirred suspension of potassium tert-butoxide (1.06 g, 9.42 mmol) in THF (300 mL) cooled to 0 C. in an ice-bath was added a solution of 2,2′-oxydiethanol (4.60 g, 78.0 mmol) in THF (10 mL). The mixture was stirred at 0 C. for 30 min and was then allowed to warm to RT and was treated dropwise with propargyl bromide (1.68 mL of an 80% solution in toluene, 11.30 mmol). The reaction mixture was stirred at RT for 16 hr and diluted with brine and water (5:1, 50 mL) and was extracted with EtOAc (3*500 mL). The combined organic extracts were dried, filtered and evaporated in vacuo. The residue was purified by flash column chromatography, eluting with 25 to 60% EtOAc in heptane, to afford the title compound (10) (410 mg, 30%) as a yellow oil: 1H NMR (250 MHz, CDCl3) delta: 2.22 (1H, s), 2.45 (1H, t), 3.58-3.66 (2H, m), 3.67-3.79 (6H, m), 4.22 (2H, d).

According to the analysis of related databases, 111-46-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; King-Underwood, John; Ito, Kazuhlro; Murray, Peter John; Hardy, George; Brookfield, Frederick Arthur; Brown, Christopher John; US2012/208799; (2012); A1;,
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The origin of a common compound about 2-(o-Tolyl)ethanol

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19819-98-8, 2-(o-Tolyl)ethanol.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19819-98-8, name is 2-(o-Tolyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 19819-98-8

The phenylacetaldehydes 6a-n were prepared by oxidation of the corresponding phenylethyl alcohols using dipyridine chromium (VI) oxide (Collin’s reagent) in dry dichloromethane at 25 C. according to reported procedures.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19819-98-8, 2-(o-Tolyl)ethanol.

Reference:
Patent; The Governors of the University of Alberta; US2011/9492; (2011); A1;,
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Brief introduction of 3-Amino-1,1,1-trifluoropropan-2-ol

The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, the common compound, a new synthetic route is introduced below. Formula: C3H6F3NO

A solution of 150 mg intermediate 17, 1 12 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 248 mg HATU and 0.23 mL ethyldiisopropylamine in 7.5 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.1 Vol% formic acid)-gradient)) to yield 130 mg 6-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypropyl)-2,3- dihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-de): delta = 3.47 (ddd, 1 H); 3.75 (ddd, 1 H); 4.17-4.27 (m, 1 H); 6.66 (d, 1 H); 7.39 (ddt, 1 H); 7.53-7.66 (m, 5H); 8.00 (d, 2H); 8.67 (s, 1 H); 9.64 (t, 1 H).

The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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Sources of common compounds: 4-(Hydroxymethyl)cyclohexanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33893-85-5, 4-(Hydroxymethyl)cyclohexanol, other downstream synthetic routes, hurry up and to see.

Application of 33893-85-5, Adding some certain compound to certain chemical reactions, such as: 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol,molecular formula is C7H14O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33893-85-5.

Operation steps: The four-necked flask is equipped with a stirring paddle, a thermometer, a water separator, and a reflux condenser is connected to the upper part of the water separator. 150.2g of p-methylolcyclohexanol and 92g of acrylic acid were placed in a 500mL four-necked flask, and 4.2g of p-hydroxyanisole, 8.6g of p-toluenesulfonic acid, 1.95g of hypophosphorous acid, and 80g of toluene were added. After stirring, the vacuum pump was started at 30KPa When the temperature is raised to 86 C, the reflux flow rate of the solvent in the reflux condenser is stable, and a water layer appears in the water separator. The water output is recorded once every hour. When the water output is less than 0.1g / h, the reaction is completed and the reaction time is 16 ~ 18h.After the reaction, the temperature was lowered to 45 C., 80 g of toluene was added to the product after the reaction, and 50 g of water was added for washing. After stirring at 40 C. for 5 minutes, it was placed in a separating funnel and allowed to stand for water separation. At 40 C, 50g of 1N sodium bicarbonate and 1N sodium hydroxide aqueous solution were added to neutralize, and the mixture was left standing to separate water. This operation was repeated 3 times. After neutralization is completed, add 0.3g of p-hydroxyanisole, spin-dry the solvent,Obtained colorless transparent viscous monomer A3,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33893-85-5, 4-(Hydroxymethyl)cyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Boxing New Materials Technology Co., Ltd.; Huang Lijiang; Pang Laixing; Li Zhiyun; Wang Hui; Su Hang; Tan Haiding; Li Lin; (11 pag.)CN110452191; (2019); A;,
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Some tips on 2-(3-Bromophenyl)propan-2-ol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30951-66-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 30951-66-7, 2-(3-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 30951-66-7, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(3-Bromophenyl)propan-2-ol

8.1 2-[3-(6-Aminopyridin-3-yl)phenyl]propan-2-ol Under an argon stream, the following are placed in a round-bottomed flask: 9.0 g of compound obtained in stage 7.1, 11.05 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine, 83.7 ml of a 2M solution of sodium carbonate and 1.70 g of tetrakis(triphenylphosphine)palladium, and dissolved in 523 ml of N,N-dimethylformamide. The mixture is heated for 1 h 30 at 80 C. After cooling to ambient temperature, 1 l of ethyl acetate is added to the reaction medium, which is filtered through celite. The organic phase is then separated, washed three times with a saturated solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. The solid obtained is triturated from diisopropyl ether, recovered by filtration and then oven-dried under reduced pressure. 2.35 g of compound are obtained. 1H NMR (DMSO-d6, delta in ppm): 1.45 (s, 6H); 5.0 (s, 1H); 6.0 (s, 2H); 6.55 (d, 1H); from 7.3 to 7.4 (m, 3H); 7.65 (s, 1H); 7.7 (d, 1H); 8.25 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30951-66-7, its application will become more common.

Reference:
Patent; SANOFI-AVENTIS; US2011/65727; (2011); A1;,
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The important role of 25392-41-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.

Reference of 25392-41-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. A new synthetic method of this compound is introduced below.

Coumarin 1 (1.77 g, 6.48 mmol) was suspended in 2 M NaOH(37 mL) and stirred at 80 C for 18 h. The resulting suspension was cooled to room temperature andacidified with concentrated hydrochloric acid to pH 1. The white precipitate was collected by vacuumfiltration and dried under reduced pressure (1.63 g, 99%); mp 154-156 C (lit. 156-157 C) [28]. H(500 MHz, DMSO-d6) 7.90 (1H, s, ArH), 7.86 (1H, s, ArH), 7.56 (1H, d, J = 8.0 Hz, ArH), 7.42 (1H, d,J = 8.25 Hz, ArH), 3.68 (2H, s, CH2). C (100 MHz, DMSO-d6) 172.2 (Cq), 155.4 (Cq), 144.8, 127.7 (Cq),126.2, 122.3, 117.3 (Cq), 114.9, 114.7 (Cq), 29.3 (CH2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.

Reference:
Article; Duncan, Luke F.; Wang, Geqing; Ilyichova, Olga V.; Scanlon, Martin J.; Heras, Begona; Abbott, Belinda M.; Molecules; vol. 24; 20; (2019);,
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Some scientific research about 111-90-0

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows. Safety of Diethylene Glycol Monoethyl Ether

EXAMPLE 14 10.7 g (0.08 mole) of ethyl carbitol was added dropwise to a mixture consisting of 1.5 g (0.04 mole) of sodium borohydride and 15 ml of xylene at 120 C. for 1.5 hours. The mixture was agitated at 120 C. for one hour. A mixture consisting of 3 g (0.02 mole) of N,N-dimethyl benzamide and 10 ml of xylene was added dropwise to the mixture over 0.5 hours. Subsequently, the resulting mixture was agitated at 120 C. for 20 hours. After cooling to room temperature, the mixture was neutralized with dilute sulfuric acid. As a result, N,N-dimethylbenzylamine was obtained in 51% yield and benzyl alcohol in 47% yield, respectively.

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

Reference:
Patent; Kao Corporation; US5196601; (1993); A;,
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A new synthetic route of 107-75-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107-75-5, its application will become more common.

Reference of 107-75-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 107-75-5 as follows.

General procedure: A solution of amine 14 in methanol (4 mL) was addedunder stirring to the corresponding aldehyde. After 3 hours NaBH4 was added to reaction mixture and stirred for an additional 1.5 hours, then the reaction mixture was treated with8 ml of saturated NaCl solution and allowed to stand for 30 minutes. The product was extracted with ether (6×10 ml).Isolation of amines 15a-d from the reaction mixture wasaccomplished by precipitation from solution in ether in theform of hydrochloric salts by adding to a solution of ethylacetatesaturated with hydrogen chloride. The precipitatewas filtered off, washed with ether and treated with saturatedsodium bicarbonate solution. The product was extractedfrom the aqueous solution with ether.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107-75-5, its application will become more common.

Reference:
Article; Ponomarev, Konstantin; Morozova, Ekaterina; Pavlova, Alla; Suslov, Evgeniy; Korchagina, Dina; Nefedov, Andrej; Tolstikova, Tat’yana; Volcho, Konstantin; Salakhutdinov, Nariman; Medicinal Chemistry; vol. 13; 8; (2017); p. 773 – 779;,
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