Month: February 2021

Synthetic Route of 62285-58-9 ,Some common heterocyclic compound, 62285-58-9, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step C: Preparation of 2-(3-(2,6-Dimethylbenzyloxy)phenyl)-2-methylpropanenitrile:; A solution of 2,6-Dimethylbenzyl alcohol (2.76g, 20.3mmol) and diisopropyl azodicarboxylate (DIAD, 4.7g, 23.2mmol) in THF (20ml) was added drop wise to a solution of 2-(3-hydroxyphenyl)-2-methylpropanenitrile (Step B, 3.2g, 19.8mmol) and triphenylphosphine (5.28g, 20.1mmol) in THF (50ml) at O0C under argon. The reaction mixture was stirred at the same temperature for 16 hours, diluted with ether and washed with water. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate, 9:1) to give the title compound

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62285-58-9, its application will become more common.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2009/151695; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.764-48-7, name is Ethylene Glycol Vinyl Ether, molecular formula is C4H8O2, molecular weight is 88.11, as common compound, the synthetic route is as follows.Safety of Ethylene Glycol Vinyl Ether

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,764-48-7, Ethylene Glycol Vinyl Ether, and friends who are interested can also refer to it.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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Related Products of 13826-35-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13826-35-2, name is (3-Phenoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 35-1-1 1-Chloromethyl-3-phenoxy-benzene; To a solution of (3-phenoxy-phenyl)-methanol (2.00 g, 10.0 mmol) in carbon tetrachloride (40 mL) was added triphenylphosphine (3.15 g, 12.0 mmol) at room temperature. The reaction solution was stirred under nitrogen atmosphere for 5 hours and 40 minutes under reflux. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (2.05 g, 94%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.37 (2H, s), 6.94-6.97 (1H, m), 7.00-7.03 (2H, m), 7.05-7.06 (1H, m), 7.13-7.20 (3H, m), 7.37-7.41 (2H, m).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13826-35-2, (3-Phenoxyphenyl)methanol.

Reference:
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
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Application of 7314-44-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

EXAMPLE 2 1,3-Dihydro-1-(2,4-dimethoxybenzyl)-3-spiro(N-methylpiperidine-4)indol-2-on A solution of 2.08 g of 1-hydroxymethyl-2,4-dimethoxybenzene in 20 ml of ether is cooled to -10 C. under nitrogen and a solution of 0.4 ml of phosphorus tribromide in 8 ml of ether is added dropwise; the resulting 1-bromomethyl-2,4-dimethoxybenzene is kept at -30 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7314-44-5, its application will become more common.

Reference:
Patent; Sanofi; US5618833; (1997); A;,
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Electric Literature of 112-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Sodium hydride (60% dispersion in mineral oil, 0.5 equiv) wasadded portion-wise to a solution of triethyleneglycol (1 equiv.) inTHF (50 mL) under nitrogen. The reaction was stirred for 1 h andthen cooled to 0 C. Benzyl bromide (0.5 equiv.) was then addeddrop-wise, and the reaction mixture was warmed to room temperatureand then stirred for 16 h. The reaction mixture was cooledin an ice bath quenched by the addition of methanol (20 mL), andthen concentrated in vacuo. The residue was dissolved in DCM(30 mL), and washed with water (30 mL). The combined organicextracts were dried over anhydrous MgSO4, filtered, and concentratedin vacuo, to afford a yellow oil, which was purified by flashchromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Article; Suthagar, Kajitha; Watson, Andrew J.A.; Wilkinson, Brendan L.; Fairbanks, Antony J.; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 153 – 166;,
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Synthetic Route of 109-83-1 , The common heterocyclic compound, 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION I; N(2-hydroxyethyl)-4-methoxy-N,2,6-trimethylbenzene-sulphonamide; A solution of 1.76 g (23.4 mM) of 2-(methylamino)ethanol is prepared in 100 ml of DCM and 5.4 g (53 mM) of triethylamine are added. The mixture is cooled to 0 C. and a solution of 5 g (21.3 mM) of 2,6 dimethyl-4-methoxybenzenesulphonyl chloride in 50 ml of DCM is added progressively. The mixture is then agitated for 3 hours at ambient temperature, and then poured over 50 ml of 0.5 N hydrochloric acid. The organic phase is separated and then washed with water, dried over magnesium sulphate and concentrated under reduced pressure. 5.8 g of the compound sought after are thus obtained as a colourless oil (yield=100%). 1H NMR (300 MHz, DMSO) delta: 6.80 (s, 2H); 4.70 (t, 1H); 3.80 (s, 3H); 3.48 (q, 2H); 3.09 (t, 2H); 2.69 (s, 3H); 2.54 (s, 6H).

The synthetic route of 109-83-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Laboratoires Fournier S.A.; US2006/178360; (2006); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 112-70-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-70-9, name is 1-Tridecanol, molecular formula is C13H28O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: L-alanine esters were preparedaccording to a procedure reported earlier.5,6 Lalanine(1.0 mmol), 1-alcohol (1.0 mmol) and ptoluenesulphonicacid monohydrate (1.2 mmol) weretaken in about 30 mL of toluene and refluxed at 110C.After 5-6 h of refluxing, the solvent was removedby rotary evaporation under reduced pressure. Theresidue was dissolved in chloroform and washed with 10% sodium carbonate and then dried with anhydrous Na2SO4.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-70-9, 1-Tridecanol.

Reference:
Article; Sivaramakrishna; Swamy, Musti J.; Journal of Chemical Sciences; vol. 127; 9; (2015); p. 1627 – 1635;,
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Reference of 3068-00-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3068-00-6, name is 1,2,4-Butanetriol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of CoCl2 (0.6 mmol) in anhyd MeCN (4 mL), the selecteddialkyl acetal (1 mmol), TMSCl (1.1 mmol), and butane-1,2,4-triol (3 mmol) were added, with stirring, at r.t. At the end ofthe reaction, the mixture was extracted with EtOAc and the combinedextracts were washed with 5% NaHCO3. The organic layerwas dried (anhyd Na2SO4) and filtered, and the solvent was evaporatedunder vacuum. The oils obtained were purified by flash chromatographyto give the desired compounds.

According to the analysis of related databases, 3068-00-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Battisti, Umberto Maria; Sorbi, Claudia; Franchini, Silvia; Tait, Annalisa; Brasili, Livio; Synthesis; vol. 46; 7; (2014); p. 943 – 946;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO

a. 4-[3-((2S,6R)-2,6-Dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-cyclohexylamine (Intermediate 17a) Sodium hydride (60% in mineral oil, 0.24 g, 6.00 mmol) was added to a stirred solution of trans-4-amino cyclohexanol (0.24 g, 2.08 mmol) in anhydrous DMF (8 mL) at RT under an argon atmosphere. The reaction mixture was stirred at RT for 30 min, then Intermediate 3c (0.50 g, 2.01 mmol) in anhydrous DMF (7 mL) was added and stirred at 60 C. for 4 h. After cooling, the reaction mixture was quenched by careful addition of a saturated aqueous solution of NH4Cl and water (1:1) and extracted with DCM (3*50 mL). The combined organic layers were washed with water followed by brine, dried and concentrated in vacuo. The resultant residue was purified by FCC using 0-10% [2M NH3 in MeOH] in DCM to afford the title compound (0.61 g, 88%) as a brown oil. LCMS (Method 3): Rt 2.19 min, m/z 344 [MH+].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; WOO, Chi-Kit; ALCARAZ, Lilian; CAPALDI, Carmelida; US2014/364411; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 10029-04-6 ,Some common heterocyclic compound, 10029-04-6, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Ethyl 2-(hydroxymethyl)acrylate 3 (1470 mg, 11.31 mmol), triphenylphosphine (3259 mg, 12.44 mmol) and BocNHTos (3360 mg, 12.44 mmol) were dissolved in dry THF (110 mL). Diisopropyl azodicarboxylate (2512 mg, 12.44 mmol) was slowly added at 0 C and the reaction mixture was stirred at room temperature for 24 h. Evaporation of the solvent and purification by flash chromatography on silica gel (petroleum ether/EtOAc 9:1) afforded pure compound 4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10029-04-6, its application will become more common.

Reference:
Article; ?ukauskaite, Asta; Mangelinckx, Sven; Callebaut, Gert; Wybon, Clarence; ?a?kus, Algirdas; De Kimpe, Norbert; Tetrahedron; vol. 69; 16; (2013); p. 3437 – 3443;,
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