Electric Literature of 722-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.
A mixture of 2-(4-amino-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (1 eq.), DIAD(1.96 eq.), PPh3(polymer-bound, 2.36 eq) and MeOH (1.1 eq) in THF (100 mL)was stirred at reflux for 16 h. After filtration andconcentration, the crude was purified by flashchromatography (20percent EtOAc/CH2Cl2) to give the title compoundas a white solid. MS (ES+) : 274 (M+H)+. Calc’d forCioH9F6NO- 273.06.
The chemical industry reduces the impact on the environment during synthesis 722-92-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AMGEN INC.; WO2006/12374; (2006); A1;,
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