Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C13H26O6
3,6,9-Trioxadodecan-12-oic acid, l-[[3-trifluoromethyl-7-oxa-bicyclo[2.2.1]hepta-2,5- diene-2-carboxyl]oxy]-l,l-dimethylethyl ester (10); A mixture of 5 (103 mg, 0.50 mmol), tert-butyl-12-hydroxy-4,7,10-trioxadodecanoate (139 mg, 0.50 mmol) and 4-(dimethylamino)-pyridine (DMAP, 121 mg, 1.00 mmol) in CH2Cl2 (6 mL) was cooled to 0 0C before adding l-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCHCl, 105 mg, 0.55 mmol). The mixture was stirred for 5 min. at 0 0C and 18 hours at room temperature. The reaction mixture was acidified with HCl (2M) to a pH of 1-2 and extracted with CH2Cl2 (2 x 10 mL). The combined organic layers were dried over MgSO4 and concentrated in vacuo. The crude mixture was purified by preparative TLC (CH2Cl2/Me0H, 9/1) resulting in compound 10 as a slightly yellow oil (65 mg (27%)). Rf= 0.81 (CH2Cl2/Me0H, 9/1). 1H-NMR (400 MHz, CDCl3) delta (ppm):
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Reference:
Patent; STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN; STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN; WO2008/75955; (2008); A2;,
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