Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 124-76-5, name is Isoborneol. A new synthetic method of this compound is introduced below., Quality Control of Isoborneol
Example 8 Preparation of 1-[((1S)-endo)-(-)-bornyloxy]-5-(2-propenyl)-2-oxabicyclo[3.3.0]octane [(18a), (18b)] 16.9 parts of ((1S)-endo)-(-)-borneol (10) was added to a solution prepared by adding 21.0 parts of 2-(2-acetoxyethyl)-2-(2-propenyl)cyclopentanone (21) and 2.5 parts of pyridinium paratoluene sulfonate to 173 parts of toluene at room temperature. The mixture was stirred for 10 hours at 110C. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (n-hexane: diethyl ether = 40: 1) to obtain 25.9 parts of the target isomer mixture. The isomer mixture was developed by silica gel thin layer chromatography using a 2:1 mixture of n-hexane and toluene as a developing solution to confirm that the Rf values were 0.28 (Isomer 9) and 0.36 (Isomer 10) when developed for 44 mm.
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Reference:
Patent; Zeon Corporation; EP1535917; (2005); A1;,
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