Application of 39895-56-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39895-56-2, name is (4-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.
Furthermore, 4-(4,6-dichloro-1,3,5-triazin-2-yl)morpholine (9a, Scheme 2; 0.588 g, 2.5 mmol),(4-(aminomethyl)phenyl)methanol (1 eq., 0.343 g, 2.5 mmol), and K2CO3 (1 eq., 0.343 g, 2.5 mmol)were combined in a flask. The solid material was dissolved in DMF (10 mL), and was stirred for 72 h atroom temperature (heated if necessary on the last day). Brine (100 mL) was added to the flask and theproduct was precipitated. The solid was filtered and dried overnight under high vacuum. The productwas purified using column chromatography (silica) with 50% ethyl acetate in hexanes as the eluent.White product (10b, Scheme 2) was produced (0.428 g, 1.28 mmol, 51%). 1H-NMR (300 MHz, CDCl3) delta 7.29 (m, 4H), 5.92 (s, 1H), 4.69 (s, 2H), 4.57 (d, J = 6.1 Hz, 2H), 3.79 (m, 4H), 3.69 (t, J = 4.6 Hz, 4H),1.88 (br s, 1H). 13C-NMR (101 MHz, DMSO-d6) delta 169.35, 168.74, 166.01, 165.66, 164.46, 164.32, 141.59,137.98, 137.93, 127.65, 127.30, 126.91, 126.87, 66.16, 63.15, 44.00, 43.95. Most 13C-NMR resonances showevidence of two conformers due to hindered rotation around the C-NHR bond.
The chemical industry reduces the impact on the environment during synthesis 39895-56-2, I believe this compound will play a more active role in future production and life.
Reference:
Article; Nelson, Ronald A; Schronce, Taylor; Huang, Yue; Albugami, Alanoud; Kulik, George; Welker, Mark E.; Molecules; vol. 23; 7; (2018);,
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