Related Products of 10602-04-7 ,Some common heterocyclic compound, 10602-04-7, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 4 (2.04 g, 15.44 mmol) in 1 ml of DCM (Dichlormethane) was cooled to 0¡ã C. MsCl methanesulfonyl chloride (1.383 ml, 17.75 mmol) and Triethylamine (2.474 ml, 17.75 mmol) were added and the mixture was heated in a microwave oven at 100¡ã C. for 20 min. The mixture was quenched with saturated NaHCO3 (0.8 ml) and extracted with DCM. The organic layers were washed with water, dried over MgSO4, filtered and concentrated under vacuum to afford 5 (2.004 g, 13.31 mmol, 86percent yield) as a yellow oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITE DE FRIBOURG; Fromm, Katharina; Bochet, Christian; (27 pag.)US9758545; (2017); B2;,
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