Electric Literature of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.
The product from step 1 (500 mg, 1.9 [MMOL)] and ethyl acetoacetate [(0. 27] mL, 2.1 [MMOL)] were combined and dissolved in methanol (10 mL) at ambient temperature. To this solution was added glacial acetic acid (0.13 mL, 2.1 [MMOL)] followed by sodium [CYANOBOROHYDRIDE] (194 mg, 3.1 [MMOL).] After stirring 18 h, the solution was [CONCENTRATED IN VACUO] and the resultant oil dissolved in ethyl acetate. The organics were washed with brine, dried over [MGS04,] and concentrated. Purification by reverse phase HPLC using a gradient elution of 60: 40 H20/TFA : CH3CN to 0: 100 H20/TFA : CH3CN at 254 nm afforded the title compound as a white solid (440 mg, [61 percent)] : mp = 103 [¡ãC.] H NMR [(CDC . S) 8] 7.43 (d, 2H), 6.64 (d, 2H), 4.07 (q, 2H), 3.90 (m, 1H), 3.43 (br s, 1 H), 2.58 (dd, 1 H), 2.41 (dd, [1 H),] 1.23 (d, 3H), 1.17 (t, 3H). MS (ES+) m/z 374 [(MH+).] [ANAL. CALC.] for C15H17NO3F6: C, 48.26 ; H, 4.59 ; N, 3.75. Found: C, 47.95 ; H, 4.45 ; N, 3.58.
According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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