Synthetic Route of 702-82-9 ,Some common heterocyclic compound, 702-82-9, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 5- (4-fluorophenyl) -7-trifluoromethylpyrazolo [1,5-a] pyrimidine-3-carboxylic acid (18, 3.08 mmol) obtained in the step 4) -dimethylaminopropyl) -3-ethylcarbodiimide (1.182 g, 6.18 mmol), 4-dimethylaminopyridine (0.3858, 3.08 mmol), 1-hydroxybenzotriazole (0.4158, 3.08 mmol ), 3-hydroxyamantanamine (4.62 mmol) and mixing to give a mixture I; sealing the vessel in which said mixture I is located, evacuating, passing nitrogen;After repeating the above steps three times, tetrahydrofuran and dimethylformamide were added to the mixture I under a nitrogen atmosphere to obtain a mixture; the tetrahydrofuran and TN, N-dimethylformamide were both dried and anhydrous ; Heating the mixture to a temperature of 40 C and heating for 6 hours, extracting, washing with water, combining and showing signs of drying to the mixture K; the extraction is carried out using a mixture of ethyl acetate Ester extraction, and the extraction process was repeated three times; the water washing process was repeated twice; and the drying was carried out using anhydrous sodium sulfate. The mixture K is subjected to distillation under reduced pressure to precipitate a solid; and the precipitated solid is filtered and washed to obtain a product. The washing was carried out using a mixed solution of ethyl acetate and n-hexane.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chongqing Medical College; SHI, LEI; NIU, YA HUI; (10 pag.)CN105884783; (2016); A;,
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