Related Products of 395-23-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.
Example 171: l-(4-Fluorophenyl)-3-(phenyl(4-(trifluoromethyl)phi methyl)ureaStep 1. Phenyl(4-(trifluoromethyl)phenyl)methanoneA solution of 4-(trifluoromethyl)benzhydrol (1.836 g, 7.3 mmol) in anhydrous DCM (65 mL) was treated with manganese(IV) oxide (<5 micron, activated) (5.7 g, 66 mmol). The resulting suspension was stirred at rt for 12 days. The catalyst was removed by filtration through a Celite brand filter agent pad. The filtrate was concentrated, and the resulting solid was dried under high vacuum to afford the title compound as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,395-23-3, its application will become more common.
Reference:
Patent; AMGEN INC.; BROWN, James; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; LIU, Qingyian; MONENSCHEIN, Holger; NGUYEN, Thomas T.; NISHIMURA, Nobuko; ZHONG, Wenge; WO2012/177896; (2012); A1;,
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