Reference of 25392-41-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. A new synthetic method of this compound is introduced below.
Coumarin 1 (1.77 g, 6.48 mmol) was suspended in 2 M NaOH(37 mL) and stirred at 80 C for 18 h. The resulting suspension was cooled to room temperature andacidified with concentrated hydrochloric acid to pH 1. The white precipitate was collected by vacuumfiltration and dried under reduced pressure (1.63 g, 99%); mp 154-156 C (lit. 156-157 C) [28]. H(500 MHz, DMSO-d6) 7.90 (1H, s, ArH), 7.86 (1H, s, ArH), 7.56 (1H, d, J = 8.0 Hz, ArH), 7.42 (1H, d,J = 8.25 Hz, ArH), 3.68 (2H, s, CH2). C (100 MHz, DMSO-d6) 172.2 (Cq), 155.4 (Cq), 144.8, 127.7 (Cq),126.2, 122.3, 117.3 (Cq), 114.9, 114.7 (Cq), 29.3 (CH2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.
Reference:
Article; Duncan, Luke F.; Wang, Geqing; Ilyichova, Olga V.; Scanlon, Martin J.; Heras, Begona; Abbott, Belinda M.; Molecules; vol. 24; 20; (2019);,
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