Reference of 107-75-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 107-75-5 as follows.
General procedure: A solution of amine 14 in methanol (4 mL) was addedunder stirring to the corresponding aldehyde. After 3 hours NaBH4 was added to reaction mixture and stirred for an additional 1.5 hours, then the reaction mixture was treated with8 ml of saturated NaCl solution and allowed to stand for 30 minutes. The product was extracted with ether (6×10 ml).Isolation of amines 15a-d from the reaction mixture wasaccomplished by precipitation from solution in ether in theform of hydrochloric salts by adding to a solution of ethylacetatesaturated with hydrogen chloride. The precipitatewas filtered off, washed with ether and treated with saturatedsodium bicarbonate solution. The product was extractedfrom the aqueous solution with ether.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107-75-5, its application will become more common.
Reference:
Article; Ponomarev, Konstantin; Morozova, Ekaterina; Pavlova, Alla; Suslov, Evgeniy; Korchagina, Dina; Nefedov, Andrej; Tolstikova, Tat’yana; Volcho, Konstantin; Salakhutdinov, Nariman; Medicinal Chemistry; vol. 13; 8; (2017); p. 773 – 779;,
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