Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16369-21-4, name is 2-(Propylamino)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H13NO
PREPARATION EXAMPLE 8 N-[2-(1-Adamantyloxy)ethyl]propylamine hydrochloride (Intermediate No. 8-1) 2-(Propylamino)ethanol (2.4 g, 23 mmol) was mixed with 1-bromoadamantane (0.50 g, 2.3 mmol) and triethylamine (0.32 ml, 2.3 mmol), and the mixture was stirred at an external temperature of 100 C. for two hours, at 130 C. for five hours and at 150 C. for three hours. The reaction mixture was allowed to stand, then ethyl acetate (50 ml) was added to the reaction mixture, and the whole was washed with water (50 ml) twice and saturated brine (30 ml) successively. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography, a 4 N solution of hydrogen chloride in ethyl acetate (2 ml) was added to the separated substance, and the whole was concentrated under reduced pressure. The resulting crystals were filtered off with ethyl acetate to give 0.16 g (25%) of the titled compound as colorless crystals. IR(KBr): 3544, 2907, 2502, 1584 cm-1 mp: 232.0-232.7 C.
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Reference:
Patent; Ban, Masakazu; Suhara, Hiroshi; Horiuchi, Masato; Yamamoto, Noriyoshi; Enomoto, Hiroshi; US2003/32623; (2003); A1;,
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