Adding a certain compound to certain chemical reactions, such as: 61487-25-0, (2-Amino-3-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Amino-3-chlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (2-Amino-3-chlorophenyl)methanol
Example 82 Preparation of 2-chloro-6-methoxymethylaniline A solution of 4.00 g (25.4 mmol) of 2-amino-3-chlorobenzyl alcohol in 30 ml of dry THF was cooled to -78C, treated with 16.7 ml (26.7 mmol) of 1.60 M n-butyllithium in hexane, warmed to 0-5C, treated with 3.61 g (25.4 mmol) of methyl iodide and heated at reflux for 5.5 hours. The solvent was removed by evaporation at reduced pressure. The residue was partitioned between 175 ml of ether and water, and the organic phase was separated and dried (MgSO4). The solvent was removed by evaporation at reduced pressure, and the residue was purified by HPLC eluding with EtoAc-hexane (5:95, v/v) to afford 1.1 g of the desired product as a pale brown oil. IR and 1H NMR spectra were in agreement with the assigned structure.
The synthetic route of 61487-25-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
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