Electric Literature of 629-41-4 , The common heterocyclic compound, 629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 4 The following example describes the synthesis of (E,Z)-8,10-pentadecadien-1-ol acetate. 8-[(Tetrahydro-2H-pyran-2-yl)oxy]-1-octanol. 1,8-Octanediol (16.8 g) (115 mmol) and 4.83 g of dihydropyran (57.5 mmol) in 1400 ml of dichloromethane containing 5 drops of concentrated HCl were stirred for 2 hours. Then 10 g of NaHCO3 were stirred in and the solution was filtered. Dichloromethane was removed with a rotary evaporator, and the resulting residue was triturated with pentane; the undissolved solid was 1,8-octanediol. The solid was filtered from the pentane solution, and the pentane was removed with a rotary evaporator to give 13.2 g (99.8%) of crude product oil.
The synthetic route of 629-41-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The United States of America as represented by the Secretary of Agriculture; US5607670; (1997); A;,
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