Related Products of 4704-94-3 , The common heterocyclic compound, 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(1 a) 5,9-dioxaspiro[3.51non-7-ylmethanolCyclobutanone (3.3 g, 47.1 mmol), 2-(hydroxymethyl)-1 ,3-propanediol (5 g, 47.1 mmol), p-toluenesulfonic acid monohydrate (450 mg, 2.37 mmol), and benzene (50 ml) were mixed together in a round-bottom flask equipped with a Dean-Stark and a cooling tube, and the mixture was stirred for 6 hours under reflux, and then allowed to stand at room temperature overnight. Triethylamine (2 ml) was added to the reaction mixture, and then the reaction liquid was concentrated. The resulting residue was purified by silica gel column chromatography (silica gel, eluent: heptane / ethyl acetate = 1 / 1 -1 / 3 gradient), whereby the title compound (5.56 g, yield 67.1 %) was obtained as a colorless oil.1H-NMR (400 MHz, DMSO-d6) delta ppm: 1.56-1.66 (2H, m), 1.66-1.76 (1 H, m), 2.05-2.15 (4H, m), 3.33 (2H, dd, J = 5, 6 Hz), 3.50 (2H1 dd, J = 8, 12 Hz), 3.76 (2H, dd, J = 4, 12 Hz), 4.54 (1 H, t, J = 5 Hz).
The synthetic route of 4704-94-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai R & D Management Co., Ltd.; WO2008/47849; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts