As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 2240-88-2
Under argon, 100mg (0.213 mmol) of 4-hydroxy-5,5-dimethyl-2-{2-methyl-8-[(2,3,6-trifluorobenzyl)oxy]imidazo[1 ,2-a]pyridin-3-yl}-5,7-dihydro-6H-pyrrolo[2,3-d] pyrimidin-6-one (Example 11), 26 mg (0.23 mmol) of 3,3,3-trifluoropropan-1-ol and 60 mg (0.23 mmol) of triphenylphosphine were suspended in 0.84 ml of THF, the mixture was mixed in an ultrasonic bath for 10 mm, 49 mg (0.230 mmol) of diisopropyl azodicarboxylate (DIAD) were then added and the mixture was stirred at RT overnight. A further 9 mg (0.08 mmol) of 3,3,3-trifluoropropan-1-ol, 20 mg (0.08 mmol) of triphenylphosphine and 15 mg (0.07 mmol) of diisopropyl azodicarboxylate were added, and the mixture was stirred at RT overnight. The reaction mixture was purified by preparative HPLC (RP-C1 8, mobile phase:acetonitrile/water gradient with addition of 0.05percent formic acid). This gave 48 mg (40percent of theory) of the target compound.11053] LC-MS (Method 1): R=1.04 mm11054] MS (ESIpos): mlz=566 [M+H]11055] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=1.34 (s, 6H), 2.76 (s, 3H), 2.83-2.95 (m, 2H), 4.69-4.75 (m, 2H),5.39 (s, 2H), 7.00-7.05 (m, 1H), 7.07-7.11 (m, 1H), 7.25-7.34 (m, 1H), 7.62-7.72 (m, 1H), 9.52 (dd, 1H), 11.36 (s, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 2240-88-2.
Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; GROMOV, Alexey; FOLLMANN, Markus; BROCKSCHNIEDER, Damian; STASCH, Johannes-Peter; MARQUARDT, Tobias; TERSTEEGEN, Adrian; WUNDER, Frank; REDLICH, Gorden; LANG, Dieter; LI, Volkhart Min-Jian; (95 pag.)US2016/347770; (2016); A1;,
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