Synthetic Route of 17849-38-6 , The common heterocyclic compound, 17849-38-6, name is 2-Chlorobenzyl alcohol, molecular formula is C7H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: DBDMH (20 mmol) was added in portion wise to a mixture of 1b (5 mmol) andmethanol (30 ml). The reaction was kept at room temperature. After the mixture wasstirred for 12h, the methanol was vacuum evaporated. The residue was dissolved byMTBE (30 ml), washed with water (330 ml).The organic extracts was dried byanhydrous MgSO4, filtered, and concentrated under reduce pressure. The residue waspurified by column chromatography (silica gel: petroleum ether/ethyl acetate, 30:1) toafford the product as light yellow solid ( 92% yield).
The synthetic route of 17849-38-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Zhongzhou; Zhu, Wei; Bao, Jinlong; Zou, Xinzhuo; Synthetic Communications; vol. 44; 8; (2014); p. 1155 – 1164;,
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