Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below., Safety of Ethyl 6-hydroxyhexanoate
1.4 Synthesis of ethyl 6-[(2-cyanoethyl)( V, V-diisopropylamino)phosphino] oxyhexanoate. Ethyl 6-hydroxyhexanoate (2.44 mL, 15.0 mmol) and diisopropylethylamine (10.4 mL, 60.0 mmol) were dissolved in CH2C12 (60 mL). 2-Cyanoethyl-N,N- diisopropylchlorophosphoramidite (3.51 mL, 15.8 mmol) was added dropwise, and the reaction was stirred for 2 h. The reaction was washed with ice-cold saturated aqueous NaHC03, dried over Na2S04, filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography (Si02, 9: 1 hexane/EtOAc with 0.1%> Et3N) to yield the product (4.20 g, 1 1.7 mmol, 78%) as a colorless liquid. i? 0.80 (2: 1 hexane/EtOAc). Spectral data matched those reported previously (Raddatz et al. , 2002, Nucleic Acids Res. 30, 4793).
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Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; LAMBRIS, John D.; RICKLIN, Daniel; WO2015/142701; (2015); A1;,
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