Application of 2919-23-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.
To a solution of cyclobutanol (500 mg, 6.93 mmol), methane sulfonyl chloride (0.810 mL, 10.40 mmol) in DCM (5.0 mL) was added TEA (2.90 mL, 20.80 mmol) at 0 C. The mixture was stirred at 25 C for 3 h. TLC showed that the reaction was completed. The reaction mixture was diluted with EhO (50 ml) and DCM (30 ml), organic layer was separated, washed with EhO (20 mL *3), dried and concentrated. The residue was purified by silica gel column (pet. ether/EtOAc = 10: 1) to afford cyclobutyl methane sulfonate (350 mg, 1.864 mmol, 26.9 % yield) as yellow oil.
The chemical industry reduces the impact on the environment during synthesis 2919-23-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; GILLIS, Eric P.; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M.; (367 pag.)WO2019/244066; (2019); A2;,
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