Related Products of 558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 6-(tert-butylsulfonyl)-4-chloroquinolin-7-ol (250 mg, 0.834 mmol) in DMF (2756 mu) was added K2C03 (576 mg, 4.17 mmol) followed by l-chloro-2- methylpropan-2-ol (209 mu, 2.502 mmol). After 10 min, LCMS showed no product. Heated reaction to 60 ¡ãC. No reaction after 3 hr at this temperature. Added sodium iodide (375 mg, 2.50 mmol) and 2,2-dimethyloxirane (371 mu, 4.17 mmol) and stirred for 2 days at to 60 ¡ãC. The crude sample was purified via Biotage normal phase chromatography (25g SNAP column, 0percent – 80percent, 80percent. hex / EtOAc). The pure product containing-fractions were combined and concentrated leading to the product as an off-white solid: -{{6-{tert- butylsulfonyl)-4-chloroquinolin-7-yl)oxy)-2-methylpropan-2-ol (46 mg, 0.124 mmol, 14.83 percent yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.29 (s, 6 H) 1.33 (s, 9 H) 4.03 (s, 2 H) 4.56 (s, 1 H) 7.72 (s, 1 H) 7.76 (d, J=4.80 Hz, 1 H) 8.64 (s, 1 H) 8.94 (d, J=4.80 Hz, 1 H). MS (m/z) 372.2 (M+H+).
According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE LLC; CASILLAS, Linda, N.; DEMARTINO, Michael, P.; HAILE, Pamela, A.; MEHLMANN, John, F.; RAMANJULU, Joshi, M.; SINGHAUS, Robert, Jr.; WO2014/43437; (2014); A1;,
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