Reference of 623-50-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 623-50-7, name is Ethyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below.
General procedure: General Procedure A. Alkylation of N9: To a solution of purine 3 (1.0 eq) in THF (0.1 M) at room temperature, was added the appropriate alcohol (1.1 eq) followed by triphenylphosphine (PPh3; 1.1 eq) under an N2 atmosphere. To the stirring solution, diisopropylazodicarboxylate (DIAD, 1.0 eq) was added dropwise (over 30 s). According to TLC visualization the reaction was complete after 15 min and the solvent was removed in vacuo. The resulting residue was adsorbed onto silica gel from CH2Cl2, and purified by flash column chomatography (2:1 EtOAc:Hex).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-50-7, Ethyl 2-hydroxyacetate, and friends who are interested can also refer to it.
Reference:
Article; Shahani, Vijay M.; Ball, Daniel P.; Ramos, Allan V.; Li, Zhihua; Spagnuolo, Paul A.; Haftchenary, Sina; Schimmer, Aaron D.; Trudel, Suzanne; Gunning, Patrick T.; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5618 – 5628;,
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