Electric Literature of 109-83-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, molecular weight is 75.1097, as common compound, the synthetic route is as follows.
[Step 2] Fabrication of 2-Acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene 0.4 g (2.1 mmol) of the second compound 2 is obtained to be mixed with 1.8 g (24.0 mmol) of 2-methylaminoethanol (CH3NHCH2CH2OH), 2.0 g (19.2 mmol) of sodium bisulfite (Na2O5S2) and 4 mL of water to be heated to 140 celsius degrees ( C.) with vigorous stirring and refluxed for 76 hrs. After cooling, 50 mL of dichloromethane is added for phase separation after sufficient stirring. Therein, after being dried with anhydrous sodium sulfate, an organic phase is concentrated under reduced pressure and separated and purified by liquid chromatography (SiO2, EtOAc_CH2Cl2=1:3), with 0.15 g (0.81 mmol) of the second compound 2 recycled. Thus, a solid product, 2-acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene 3 (hereinafter referred to as third compound 3), is obtained, which has a weight of 0.276 g and a yield of 88.0%.
Statistics shows that 109-83-1 is playing an increasingly important role. we look forward to future research findings about 2-(Methylamino)ethanol.
Reference:
Patent; INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.; Lin, Wuu-Jyh; Farn, Shiou-Shiow; Tu, Yean-Hung; Huang, Li-Yuan; Chen, Dow-Che; Chu, Kuo-Yuan; Chang, Mao-Hsung; Duh, Ting-Shien; Chen, Jenn-Tzong; Shiue, Chyng-Yann; US9186423; (2015); B1;,
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