Adding a certain compound to certain chemical reactions, such as: 19064-18-7, (2,6-Difluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,6-Difluorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,6-Difluorophenyl)methanol
3-(4-N,N-dimethylaminomethyl)phenyl-2-chloro-6-bromoquinoline(60 mg, 0.16 mmol) was dissolved in 2 mL of anhydrous tetrahydrofuran,Followed by addition of 2,6-difluorobenzyl alcohol (46 mg, 0.32 mmol),60% sodium hydride (30 mg, 0.78 mmol) was added and the reaction was stirred at room temperature for 8 hours.The organic phases were combined, concentrated to dryness and chromatographed on a column (dichloromethane / methanol 25: 1), dried over MgSO4,To give 63 mg of a pale yellow oil in 81.68% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19064-18-7, (2,6-Difluorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Institute of Materia Medica,Chinese Academy of Medical Sciences; He, Chunxian; Cui, Huaqing; Yin, Dali; (66 pag.)CN106167464; (2016); A;,
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Alcohols – Chemistry LibreTexts