Application of 637031-88-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 637031-88-0, name is 3,3-Difluorocyclobutanol, molecular formula is C4H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 7′-methylsulfonylspiro[l,3- dioxolane-2,l’-indane]-4′-ol (2.0 g, 7.4 mmol), triphenylphosphine (8.2 g, 31.1 mmol), and 3,3-difluoro-cyclobutanol (1.04 g, 9.6 mmol) in tetrahydrofuran (50 mL) at 60 C was added diisopropyl azodicarboxylate (2.3 mL, 11.8 mmol). After addition, the reaction mixture was stirred at 60 C overnight. After cooled to ambient temperature, water (50 mL) and MTBE (50 mL) were added. The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue obtained was purified by flash chromatography on silica gel to give 4′-(3,3-difluorocyclobutoxy)-7′-methylsulfonyl- spiro[l,3-dioxolane-2,l’-indane] (1.0 g, 37%) as solid.
According to the analysis of related databases, 637031-88-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; (237 pag.)WO2016/144825; (2016); A1;,
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