Related Products of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.
(1) primary crystals(2,6-dichloro-3-fluorophenyl into an (S) -1-; 30g Compound (2) was added 105mL of petroleum ether obtained in Preparation Example 1 embodiment taken, heated and stirred under argon for 40 , dissolve yl) ethanol seed, after 45min, a seed crystal was smaller; after 1 hour, the disappearance of seed; 3.5h, the precipitated white solid (precipitated to the bottom); 10H, no further solid separated; dry filtration dry, weighing 20g, yield 66.7%; chiral phase detection ee: 60.5% (test conditions AD-H; n-hexane (0.1% acetic acid): isopropanol = 80: 20; 0.3ml / L; 254nm ; 30 ).(2) secondary crystalsTake a crystalline compound obtained 30g, was added 105mL of petroleum ether, heated and stirred under argon for 40 , dissolved; into an (S) -1- (2,6- dichloro-3-fluorophenyl) ethanol seed , after 45min, a seed crystal was smaller; after 1 hour, the disappearance of seed; 3.5h, the precipitated white solid (precipitated to the bottom); 10H, no further solid separated; dry suction filtration, weighed 20g a yield of 66.7%; according to the aforementioned chromatographic conditions, chiral phase detection ee: 95.5%.(3) three times crystallizedTaking a second resultant crystalline compound 30g, was added 105mL of petroleum ether, heated and stirred under argon for 40 , dissolved; into an (S) -1- (2,6- dichloro-3-fluorophenyl) ethanol crystal species, after 45min, a seed crystal was smaller; after 1 hour, the disappearance of seed; 3.5h, the precipitated white solid (precipitated to the bottom); 10H, no further solid separated; dry suction filtration, weighed 20g, yield 66.7%; according to the aforementioned chromatographic conditions, chiral phase detection ee: 99.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.
Reference:
Patent; Xihua University; Wu, Pengcheng; Wang, Zhouyu; Jiang, Zhenju; Xu, Zhihong; Weng, Guanglin; Tan, Ping; Liu, Siyu; (10 pag.)CN105237346; (2016); A;,
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