Synthetic Route of 6240-11-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of Intermediate 15 (1 g, 4.3 mmol) in tetrahydrofuran (6 ml_) and 1- Adamantaneethanol (0.77 g, 4.2 mmol) in tetrahydrofuran (6 ml_) was added a solution of diethyl azodicarboxylate (2.9 mL, 6.4 mmol) and triphenylphosphine (1.6 g, 6.4 mmol) in tetrahydrofuran (4 mL). The reaction mixture was stirred at 8O0C for 48 hours. The solvent was removed under reduced pressure and partitioned between methylen chloride and water. The organic layer was washed with water, sodium hydrogen carbonate (4%) and brine. The solvent was removed under reduced pressure and the crude was purified by column chromatography with silica gel, eluting with hexane/ethyl acetate (30:1). The title compound was obtained as a solid (0.39 g, 22%). MS (M+): 414.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6240-11-5, 1-Adamantaneethanol.
Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/68177; (2009); A1;,
Alcohol – Wikipedia,
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