Related Products of 10602-04-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10602-04-7, name is (4-Ethynylphenyl)methanol, molecular formula is C9H8O, molecular weight is 132.16, as common compound, the synthetic route is as follows.
To a suspension of azide derivative 13 (1 mole eq.) in isopropanol and water (1:1) was added alkyne (2 mole eq.) followed by CuSO4H2O (0.2 mole eq.) and sodium ascorbate (0.4 mole eq.). The reaction mixture was stirred at 40-50 C for 2 h and then evaporated under reduced pressure. To the residue was added H2O and the aqueous mixture was extracted with DCM. The organic phase was washed with H2O, brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was then purified by column chromatography on silica to obtain the desired C-1 triazole derivative.
Statistics shows that 10602-04-7 is playing an increasingly important role. we look forward to future research findings about (4-Ethynylphenyl)methanol.
Reference:
Article; Bhatt, Beenu; Thomson, Robin J.; Von Itzstein, Mark; Tetrahedron Letters; vol. 52; 21; (2011); p. 2741 – 2743;,
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