Related Products of 637031-88-0 ,Some common heterocyclic compound, 637031-88-0, molecular formula is C4H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of racemic-2′,3′,4′- trifluoro-7′-methylsulfonyl-spiro[l,3-dioxolane-2, -indane] (19.3 mg, 0.063 mmol) and 3,3- difluoro-cyclobutanol (9.8 muEpsilon, 0.10 mmol) in acetonitrile (1.0 mL) at 25 C was treated with potassium hydroxide (5.3 mg, 0.094 mmol) and stirred at 25 C for 1 h. An additional portion of potassium hydroxide (5.3 mg, 0.094 mmol) was added to drive the reaction to completion. Volatiles were removed by concentration under reduced pressure. The reaction mixture was poured into 20 mL of water and extracted with 3 x 20 mL EtOAc. The combined organics were rinsed with 10 mL of brine, dried with MgS04, filtered, and concentrated to dryness. An off-white solid (27.2 mg) was isolated and used without further purification. LCMS ESI (+) [M+H]+ m/z 397.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,637031-88-0, its application will become more common.
Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; (237 pag.)WO2016/144825; (2016); A1;,
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