Adding a certain compound to certain chemical reactions, such as: 20712-12-3, (2-Amino-5-bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20712-12-3, blongs to alcohols-buliding-blocks compound. Safety of (2-Amino-5-bromophenyl)methanol
2-amino-5-bromobenzyl alcohol (4.04 g, 20.0 mmol) and diboron pinacol ester (7.65 g, 30.0 mmol, commercially available) were fully dissolved in 200 mL dioxane,Add CsCO3 (19.6 g, 60.0 mmol),PdCl2.dppf (0.88 g, 1.2 mmol) and dppf (0.55 g, 1.0 mmol),The reaction was heated at reflux.After 2 hours of reflux reaction, the reaction solution was cooled to room temperature.Insolubles are removed by filtrationEvaporate the solventResidue with water (200 ml),Extract with ethyl acetate (2 x 200 ml).The organic layer was washed with saturated saline solution.Dry with anhydrous magnesium sulfateConcentrate under reduced pressure,The residue was purified by column chromatography (eluent: EA_PE=1:3).3.39 g of a pale yellow solid.Yield 68.0percent
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20712-12-3, its application will become more common.
Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.; Li Bin; Wang Gang; Song Yuquan; Wu Shasha; Fan Xiaoxi; Shi Xuegeng; Yu Haibo; Lv Liang; (32 pag.)CN104650038; (2018); B;,
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