Reference of 5020-41-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.1904, as common compound, the synthetic route is as follows.
To a stirred mixture of 3-methoxyphenethylalcohol (1.18 g, 7.8 mmol) and pyridine (0.75 ml, 9.3 mmol) in dry dichloromethane (10 ml) was added bromine (0.47 ml, 18.0 mmol) dropwise under nitrogen at 0 C. The orange solution was stirred at room temperature for 4 hr. The reaction mixture was quenched by the addition of 10% sodium bisulfite aqueous solution., and extracted with dichloromethane. The organic extracts were washed with brine, dried over magnesium sulfate, and concentrated to give crude products, which were purified by silica-gel column chromatography eluted with gradient of hexane and ethyl acetate (10:1, 8:1, 5:1) to give the title compound as a colorless oil (1.5 g, 83.2%). [0141] 1H-NMR (CDCl3): 7.43 (d, J=8.8 Hz, 1H), 6.83 (d, J=3.3 Hz, 1H), 6.67 (dd, J=8.8, 3.3 Hz, 1H), 3.91-3.81 (m, 2H), 3.78 (s, 3H), 2.99 (t, J=6.6 Hz, 2H)
Statistics shows that 5020-41-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Methoxyphenyl)ethanol.
Reference:
Patent; Pfizer Inc.; US2003/208079; (2003); A1;,
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