Electric Literature of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.
To a mixture of 3,4-dichlorobenzyl alcohol (0.21 g, 1.20 mmol) in DMSO (5 mL) was added potassium rt-butoxide (0.29 g, 2.58 mmol). The mixture was stirred at ambient temperature for 5 minutes and 5-chloro-N-(N,N-dimethylsulfamoyl)-2,4-difluorobenzamide (Preparation 3) (0.30 g, 1.01 mmol) was added. After 0.5 h, the reaction mixture was diluted with ethyl acetate (150 mL), washed with IN hydrochloric acid (2 chi 150 mL), brine (150 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to provide a residue which was purified by HPLC using Method A. The title compound was obtained as a white solid (0.03 g, 7%): NMR (300 MHz, DMSO-de) 6 11.78 (s, 1H), 7.75-7.66 (m, 3H), 7.43 (d, J= 8.2 Hz, 1H), 7.31 (d, J= 12.1 Hz, 1H), 5.28 (s, 2H), 2.83 (s, 6H); MS (ES-) m/z 453.0, 455.0 (M – 1).
According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; DEHNHARDT, Christoph Martin; CHOWDHURY, Sultan; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HEMEON, Ivan William; SAFINA, Brian; SUTHERLIN, Daniel, P.; WO2014/8458; (2014); A2;,
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