Synthetic Route of 26021-57-8 , The common heterocyclic compound, 26021-57-8, name is 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 209.1 mg of 2-ethylbenzene-1 ,4-diamine dihydrochloride (1 mmol) and 151.1 mg of 3-aminophenol (1 mmol) in 2 ml of ethanol and 1 ml of water is adjusted to a pH of 9.5 with 20% aqueous ammonia solution. 0.21 ml of 30% aqueous hydrogen peroxide solution is then added. The reaction medium is stirred at room temperature for 5 hours. The precipitate formed is filtered off, rinsed with water-ethanol and then dried under vacuum. 148 mg of a mixture of isomers of 2-(4-amino-2 or 3-ethylphenylamino)-5-(2- hydroxyethylamino)[1 ,4]benzoquinone, compound (1 ) are isolated in the form of a green- brown powder. MS (ES+): [M+H] = 302.
The synthetic route of 26021-57-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; L’OREAL; SABELLE, Stephane; LEDUC, Madeleine; WO2014/191354; (2014); A1;,
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